MACROADENOMAS HIPOFISARIOS PDF

Introduction: Pituitary tumors comprise a quarter of the intracranial neoplasms and the adenomas represent the highest percentage of them. They are benign, but they can be invasive and they have an impact in morbidity and mortality. Objective: To analyze the clinical features of pituitary adenomas tumors, and create a computerized registry to improve strategies for diagnosis and monitoring of these patients. Methods: A retrospective, descriptive analysis of medical records of a total of patients who attended the endocrinology service from to The variables were analyzed by the corresponding descriptive statistics.

Author:Malazil Balabar
Country:Haiti
Language:English (Spanish)
Genre:Personal Growth
Published (Last):10 August 2006
Pages:435
PDF File Size:2.56 Mb
ePub File Size:19.97 Mb
ISBN:946-2-43574-297-2
Downloads:51845
Price:Free* [*Free Regsitration Required]
Uploader:Negore



Although this distinction is largely arbitrary, it is commonly used and does highlight an important fact: small intrapituitary lesions microadenomas present differently and have different surgical and imaging challenges from larger lesions macroadenomas that extend into the suprasellar region.

This article is a general overview. Pituitary adenomas are common, with rates varying widely depending on the definition: population prevalence is approximately 0.

Pituitary adenomas present either due to hormonal imbalance both microadenomas and macroadenomas or mass effect on adjacent structures macroadenomas , classically the optic chiasm. Rarely presentation can be catastrophic, due to pituitary apoplexy. Over half of all adenomas are secretory 2 , although even when this is the case this may not be the cause of presentation. A lack of libido or even galactorrhea may not lead to presentation and as such many secreting tumors are only diagnosed when mass effect occurs see below.

It is also important to note that larger tumors can lead to hormonal imbalance due to mass effect rather than secretion.

Hypopituitarism or moderately elevated prolactin are both seen, the later due to so-called stalk effect; prolactin release unlike other pituitary hormones is tonically inhibited by prolactin inhibitory hormone PIH - a. Also important to remember that numerous drugs that are dopamine antagonists will also elevate prolactin - see elevated prolactin differential 9. Most of the cases presenting due to mass effect are due to non-secreting macroadenomas 3 and the most common structure to be compressed by a macroadenoma is the optic chiasm.

Uncommonly large tumors may result in hydrocephalus by compressing the midbrain or distorting the third ventricle , orbital or sinonasal symptoms. The most commonly employed approach to pituitary masses is transsphenoidal , whereby the floor of the pituitary fossa is accessed via the nasal cavity.

In large tumors, other approaches may be necessary e. Medical management of prolactinomas relies on administering a dopamine receptor agonist e. Although it can dramatically reduce the size of a macroadenoma, it has been associated with increased incidence of hemorrhage into the tumor 4. Growth hormone secreting tumors are usually surgically resected, however in recurrent cases or in patients who are not able to undergo surgery they can be treated with octreotide a long-acting somatostatin analog.

This can result in both reduction of the size of the tumor and reduction in the serum levels of growth hormone 4,5. Radiosurgery is also occasionally used. Less common complications include damage to the optic apparatus optic nerves , chiasm , optic tracts , cranial nerves and internal carotid arteries 7.

Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. Updating… Please wait. Unable to process the form. Check for errors and try again. Thank you for updating your details. Log In. Sign Up. Log in Sign up. Articles Cases Courses Quiz. About Blog Go ad-free. As of the latest update, Google Chrome and Microsoft Edge have made a breaking change to how file uploads are handled.

Once your system installs this update, you will not be able to upload new images. Please use another browser until we can get it fixed. Depending on their size they are broadly classified into: pituitary microadenoma : less than 10 mm in size pituitary macroadenoma : greater than 10 mm in size Although this distinction is largely arbitrary, it is commonly used and does highlight an important fact: small intrapituitary lesions microadenomas present differently and have different surgical and imaging challenges from larger lesions macroadenomas that extend into the suprasellar region.

On this page:. Article: Epidemiology Clinical presentation Radiographic features Treatment and prognosis Related articles References Images: Cases and figures Imaging differential diagnosis. Quiz questions. MR imaging of pituitary adenoma: CT, clinical, and surgical correlation. Edit article Share article View revision history Report problem with Article.

URL of Article. Article information. System: Central Nervous System. Tag: endocrine. Support Radiopaedia and see fewer ads. Cases and figures. Case 1: pituitary microdenoma Case 1: pituitary microdenoma. Case 2: pituitary macroadenoma Case 2: pituitary macroadenoma.

Imaging differential diagnosis. Pituitary fossa aneurysm Pituitary fossa aneurysm. Loading more images Close Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. Loading Stack - 0 images remaining. By System:. Patient Cases. Contact Us.

LEY 23384 PDF

Adenoma hipofisário

Although this distinction is largely arbitrary, it is commonly used and does highlight an important fact: small intrapituitary lesions microadenomas present differently and have different surgical and imaging challenges from larger lesions macroadenomas that extend into the suprasellar region. This article is a general overview. Pituitary adenomas are common, with rates varying widely depending on the definition: population prevalence is approximately 0. Pituitary adenomas present either due to hormonal imbalance both microadenomas and macroadenomas or mass effect on adjacent structures macroadenomas , classically the optic chiasm.

ULN2002 PDF

[Pituitary Tumors: 10 Years of Experience]

They are defined as pituitary adenomas greater than 10 mm in size and are approximately twice as common as pituitary microadenomas. On imaging, they usually present as a solid tumor with attenuation similar to the brain HU and demonstrate moderate contrast enhancement. The same is observed on MRI, where they are isointense to the grey matter both on T1- and T2-weighted images. Patients typically present with symptoms of local mass effect on adjacent structures especially optic chiasm. Some may present hormonal imbalance, with symptoms of hypopituitarism from compression or secretion. Hormonal imbalance due to overproduction tends to present earlier and tumors are thus usually small at presentation.

UNDERSTANDING ISLAMIC FINANCE BY MUHAMMAD AYUB PDF

It is a peer reviewed journal that offers free publication and free access. Papers from all over the world are most welcome, namely from Portuguese speaking countries. We accept manuscripts in Portuguese and English. We are planning to apply for Medline indexation, so join us and take part in this project. Send us interesting case reports, your original papers and reviews. Letters to the editor will be published in short time and papers will be published online as soon as they will be accepted. Pituitary apoplexy is a rare condition, with an estimated incidence of 0.

LEM PR30 PDF

.

Related Articles